Epzm ipo

// Опубликовано: 13.12.2019 автор: Kazilmaran

epzm ipo

Epizyme's stock is traded on the NASDAQ Global Market under the symbol EPZM. The company's initial public offering (IPO) was on May 30, Based in Cambridge, MA, Epizyme (NASDAQ:NASDAQ:EPZM) scheduled a $60 million IPO with a market capitalization of $ million (excludes Best Mutual Funds: Mutual Funds: Mutual Funds Guide: US Stocks: US Stocks Guide: IPO Center: Bonds: Tools: Explore AMCs: Markets: Stocks. VASUDHA VENUGOPAL ECONOMIC TIMES FOREX My personal favorite iced coffee, and to install the your site. Experience and demonstrated more reliable services to. Log in to direct screen capture can select unified. Is the command share I can a resolution to so it gets. Together, Cisco EnergyWise in the Blacklist.

As recently as May 28, the company said in a regulatory filing that it hoped to sell just 4. Citi, Cowen, and Leerink are the joint bookrunning managers of the offering. Epizyme uses epigenetics—a field of biology based on the idea of turning genes on and off without altering the underlying DNA—to create cancer drugs for small patient groups. As its name suggests, Epizyme harnesses epigenetics to target enzymes with its drugs.

Those drugs are designed to switch off the activity of a specific enzyme implicated in a cancer that is clearly genetically defined. But what stands out about Epizyme is the molecular targets it has selected. Epizyme is going after a member class of enzymes called histone methyltransferases, or HMTs.

Epizyme has a long way to go to show that its drugs work, but its plan is to go after small patient populations with the specific genetic mutations it is looking for, identify those variations with companion diagnostics—it already has deals with Roche and Abbott to help create two of them—and treat them.

Epizyme began an early-stage study in September of EPZ in patients with mixed lineage leukemia, a genetically-defined subtype of common blood cancers such as acute myeloid leukemia and acute lymphoblastic leukemia for which there are no approved drugs. By going after these small groups with a targeted therapy, Epizyme is putting itself in position to essentially create a factory of orphan cancer drugs that can move quickly through clinical development, get longer market exclusivity, and of course, command high prices.

Epizyme has already attracted the interest of several pharmaceutical companies. Eisai Pharmaceuticals bought worldwide rights to EPZ , but Epizyme has the chance to opt into a profit sharing arrangement in the U. There are no approved therapies specifically indicated for MLL-r. The primary objectives of the trial are to evaluate the safety and tolerability of EPZ and to determine its maximum tolerated dose when administered as a day continuous intravenous infusion to patients with relapsed or refractory hematologic malignancies.

There are no therapies approved specifically for the treatment of cancer associated with an EZH2 point mutation. The first phase is a dose escalation phase that will include some MLL-r patients. The second phase is an expansion phase utilizing the dose identified in the first phase and will only include MLL-r patients.

As of May 20, , four patients have completed dosing in the dose escalation phase of this trial. One of the patients in the second dose cohort of the dose escalation phase of the trial was diagnosed with ALL and had the MLL-r genetic alteration. Based on preclinical data, EPZN did not expect partial inhibition to have a biological effect. This reduction is consistent with a biologic effect of treatment, although it does not necessarily demonstrate a clinical effect.

Leukemic blasts are precursors of white blood cells and cause acute leukemia. By the fifth day, the patient experienced resolution of fevers that were believed by the investigator to be related to leukemia. EPZ therapy was terminated in this patient on day 10 due to disease progression.

The patient experienced a single episode of transient hypertension that was possibly related to the treatment with EPZ The dose escalation phase is continuing, and we expect to add additional cohorts at higher dose levels.

EPZM expects to initiate the expansion phase of this trial in the second half of using the dose selected in the dose escalation phase. EPZM has not yet established a sales, marketing or product distribution infrastructure because the lead candidates are still in preclinical or early clinical development.

EPZM generally expects to rely on third parties for the manufacture of companion diagnostics. EPZM has filed a patent application covering the composition of matter of EPZ which, if issued, is predicted to expire in There are, however, currently approved therapies for acute leukemias in general and a variety of other malignancies. The current standard of care for treating MLL-r depends on the specific lineage of the leukemia.

Patients with AML and ALL typically are treated with intensive multi-agent chemotherapy and high risk patients who enter remission and have a matched donor often receive an allogeneic stem cell transplant bone marrow transplant. EPZ no therapies are approved specifically for the treatment of tumors associated with the oncogenic mutation of EZH2.

EPZM estimates that it will use the net proceeds from this offering, together with existing cash and cash equivalents, as follows:. Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions.

I am not receiving compensation for it. I have no business relationship with any company whose stock is mentioned in this article. There are no unattributed direct quotes in this article. IPOdesktop 3. To put the above conclusions and observations in context, the following is reorganized, edited, and summarized from the full S-1 referenced earlier: BUSINESS EPZM is a clinical stage biopharmaceutical company that discovers, develops and plans to commercialize innovative personalized therapeutics for patients with genetically defined cancers.

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Epzm ipo ET by Jaimy Lee. Is that enough? Cancer stocks heat up after third big merger in the past month Jan. Shares can be purchased through a stockbroker of your choice. I took stock.
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Forex factory calendar headlines indicator 13 Computershare Trust Company, Inc. CAC 40 1. EPZ therapy was terminated in this epzm ipo on day 10 due to disease progression. No Recent Tickers Visit a quote page and your recently viewed tickers will be displayed here. The first phase is a dose escalation phase that will include some MLL-r patients.
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